Botox for Depression Research & Information

Botulinum Toxin Therapy of Bipolar Depression: A Case Series

Eric Finzi, MD, PhD, assistant clinical professor of psychiatry at George Washington School of Medicine & Health Sciences, Department of Psychiatry and Behavioral Sciences and colleagues have found that Botulinum Toxin A has strong antidepressant properties for bipolar depression. The results showed that four of six patients with bipolar depression who were treated with Botox Cosmetic for glabellar frown lines (between the eyes) had a sustained remission of their depression. The study is published in the September 2018 issue of Journal of Psychiatric Research. Read more

Face of Emotion

In The Face of Emotion, How Botox Affects Our Mood and Relationships, Dr. Eric Finzi explains his research in narrative form, weaving personal stories and rich historical accounts to showcase how his theory came to light. Finzi's thinking, which dates back to Charles Darwin and William James's facial feedback theory, marshals together evidence from psychology, neuroscience, art, evolutionary biology, family and patients, to prove his idea that facial expressions are a central driving force of our emotions, and that there is an unlikely ally available in taming them: Botox.


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Botox for Depression, Dr. Eric Finzi, Dr. Norman Rosentha

Could Depression be Treated with Botox?

In the largest study to date on the effect of OnabotulinumtoxinA (known as Botox) on depression, researchers Eric Finzi, MD, PhD, and Norman E. Rosenthal, MD, found that 52% of subjects suffering from moderate to severe depression showed relief from depression after injection of Botox to the glabellar area between the eyes, compared with only 15% of those who received the saline placebo. The study, “Treatment of depression with onabotulinumtoxinA: A randomized, double-blind, placebo controlled trial” is published in Journal of Psychiatric Research, Volume 52 (May 2014). These findings help to confirm a novel concept for mental health - using facial expressions to influence thoughts and feelings.